Kortikosteron

Kortikosteron

Generel
Systematisk navn	4-pregnen-11β,21-diol-3,20-dion
Chem. formel	C21H30O4 _ _ _ _ _
Klassifikation
Reg. CAS nummer	50-22-6
PubChem	5753
Reg. EINECS nummer	200-019-6
SMIL	CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
InChI	InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15, 2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-, 19+,20-,21-/m0/s1OMFXVFTZEKFJBZ-HJTSIMOOSA-N
CHEBI	16827
ChemSpider	5550
Data er baseret på standardbetingelser (25 °C, 100 kPa), medmindre andet er angivet.
Mediefiler på Wikimedia Commons

Kortikosteron er et ubetydeligt og relativt inaktivt mineralokortikoidhormon i binyrebarken hos mennesker. Hos rotter er kortikosteron imidlertid det vigtigste og mest aktive glukokortikoid for det, ligesom cortisol hos mennesker.

Sammenlignet med cortisol har det en mærkbar, men meget svagere end aldosteron, mineralokortikoid aktivitet.

Links

RA Hill. Dictionary of Steroids / RA Hill, HLJ Makin, DN Kirk … [ og andre ] . — CRC Press, 23. maj 1991. — S. 189–. - ISBN 978-0-412-27060-4 .
"C-17 Hydroxylasemangel: Praksis Essentials, Patofysiologi, Epidemiologi" . 1. februar 2018 – via eMedicine.

Ordbøger og encyklopædier	Fantastisk catalansk Stor russer Britannica (online)

Steroide hormoner (endogene)

Hepatosteroider
( lever )

(S-30: Lanostanes )	Lanosterol
(S-27: Cholestans )	Zymosterol → 7-Dehydrodesmosterol → Desmosterol → Kolesterol
Galdesyrer (C-24: Cholaner )	Cholinsyre • Chenodeoxycholsyre • ‎ Deoxycholsyre • ‎ Lithocholsyre • ‎ Glycocholsyre • ‎ Glycochenodeoxycholsyre • ‎ Taurocholsyre • ‎ Taurochenodeoxycholsyre

Gonadosteroider
( gonader )

Gestogener (C-21: Pregnanes )	17α-AC: Epipregnenolon → Epiprogesteron → Epiallopregnandione → Epiallopregnanolon 17-AC: 17-Pregnenolon → 17-Progesteron → 17-Allopregnanedion → 17-Allopregnanolon 17β-AC: Pregnenolon → Progesteron → Allopregnanedion → Allopregnanolon
Androgener (C-19: Androstanes )	17α-OH: Epiandrostenediol → Epitestosteron → 5α-Dihydroepitestosteron → Epiandrostenediol 17-O: Dehydroepiandrosteron → Androstenedion → Androstenedion → Androsteron 17β-OH: Androstenediol → Testosteron → 5α-Dihydrotestosteron → Androstenediol
Østrogener (C-18: Estranes )	17α-OH: Epiestradiol → Epiestriol → Epiestretrol 17-O: Estron → Estradiolon → Estriolon 17β-OH: Østradiol → Estriol → Estetrol

Adrenosteroider
( binyrerne )

Glumerosteroider (C-21: Pregnanes )	Mineralokortikoider 11-Deoxycorticosteron → Corticosteron → 5α-Dihydrocorticosteron → 3α,5α-Tetrahydrocorticosteron Aldosteron → 5α-dihydroaldosteron → 3α,5α-Tetrahydroaldosteron 5α-Dihydrodeoxycorticosteron → 3α,5α-Tetrahydrodeoxycorticosteron Glukokortikoider 11-Deoxycortisol → Cortisol → 5α-Dihydrocortisol → 3α,5α-Tetrahydrocortisol Cortison → 5α-dihydrocortison → 3α,5α-Tetrahydrocortison 5α-Dihydrodeoxycortisol → 3α,5α-Tetrahydrodeoxycortisol
Fascillosteroider (C-19: Androstanes )	11a-hydroxy 17α-OH: 11α-Hydroxyepiandrostanediol → 11α-Hydroxyepiandrostanediol → 5α-dihydro-11α-hydroxyepistosteron → 11α-hydroxyepiandrostanediol 17-O: 11α-hydroxydehydroepiandrosteron → 11α-hydroxyandrostenedion → 11α-hydroxyandrostenedion → 11α-hydroxyandrostenedion 17β-OH: 11α-hydroxyandrostenediol → 11α-hydroxytestosteron → 5α-dihydro-11α-hydroxytestosteron → 11α-hydroxyandrostenediol 11-keto 17α-OH: 11-ketoepiandrostanediol → 11-ketoepistosteron → 5α-dihydro-11-ketoepitestosteron → 11-ketoepiandrostanediol 17-O: 11-ketodehydroepiandrosteron → 11-ketoandrostenedion → 11-ketoandrostenedion → 11-ketoandrostenedion 17β-OH: 11-ketoandrostenediol → 11-ketotestosteron → 5α-dihydro-11-ketotestosteron → 11-ketoandrostenediol 11β-hydroxy 17α-OH: 11β-hydroxyepiandrostanediol → 11β-hydroxyepitaestosteron → 5α-dihydro-11β-hydroxyepitaestosteron → 11β-hydroxyepiandrostanediol 17-O: 11β-hydroxydehydroepiandrosteron → 11β-hydroxyandrostenedion → 11β-hydroxyandrostenedion → 11β-hydroxyandrostenedion 17β-OH: 11β-hydroxyandrostendiol → 11β-hydroxytestosteron → 5α-dihydro-11β-hydroxytestosteron → 11β-hydroxyandrostenediol
Retikulosteroider (C-18: Estranes )	Katekol-østrogener 17α-OH: 2-Hydroxyepiestradiol og 4-Hydroxyepiestradiol 17-O: 2-Hydroxyestron og 4-Hydroxyestron 17β-OH: 2-hydroxyestradiol og 4-hydroxyestradiol Quinon-østrogener 17α-OH: 2,3-quinonepiestradiol og 4,3-quinonepiestradiol 17-O: 2,3-quinonestron og 4,3-quinonestron 17β-OH: 2,3-quinonestradiol og 4,3-quinonestradiol
Medullosteroider	2,3-OH DOPA → Dopamin → Noradrenalin → Adrenalin 3-OH Tryptophan → 5-hydroxytryptophan → Serotonin → N-acetyl-5-hydroxytryptamin → Melatonin 3,4-OH DOPA → Dopamin → Noradrenalin → Adrenalin