2-Hydroxyestradiol
| 2-Hydroxyestradiol |
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Systematisk
navn |
( 8R , 9S , 13S , 14S , 17S )]phenanthren-2,3,17- triol |
| Forkortelser |
2-OHE2 |
| Chem. formel |
C18H24O3 _ _ _ _ _ |
| Molar masse |
288,387 g/ mol |
| Reg. CAS nummer |
362-05-0 |
| PubChem |
247304 |
| Reg. EINECS nummer |
632-218-2 |
| SMIL |
CC12CCC3C(C1CCC2O)CCC4=CC(=C(C=C34)O)O
|
| InChI |
InChI=1S/C18H24O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9- 13(10)11/h8-9,11-12,14,17,19-21H,2-7H2,1H3/t11-,12+,14-,17-,18-/m0/s1DILDHNKDVHLEQB-XSSYPUMDSA-N
|
| CHEBI |
28744 |
| ChemSpider |
216475 |
| Data er baseret på standardbetingelser (25 °C, 100 kPa), medmindre andet er angivet. |
2-Hydroxyestradiol (2-OHE2), også kendt som estra-1,3,5(10)-trien-2,3,17β-triol , er et endogent steroid, et catechin - østrogen og en metabolit af østradiol . som en positionel isomer af østriol [1] .
Noter
- ↑ Zhu BT, Conney AH (1998). "Funktionel rolle for østrogenmetabolisme i målceller: gennemgang og perspektiver" . Carcinogenese [ engelsk ] ]. 19 (1):1-27. DOI : 10.1093/carcin/19.1.1 . PMID 9472688 .
| Steroide hormoner (endogene) |
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Hepatosteroider
( lever ) | | (S-30: Lanostanes ) |
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| (S-27: Cholestans ) |
- Zymosterol → 7-Dehydrodesmosterol → Desmosterol → Kolesterol
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Galdesyrer
(C-24: Cholaner ) |
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Gonadosteroider
( gonader ) | |
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Adrenosteroider
( binyrerne ) | Glumerosteroider
(C-21: Pregnanes ) |
Mineralokortikoider
11-Deoxycorticosteron → Corticosteron → 5α-Dihydrocorticosteron → 3α,5α-Tetrahydrocorticosteron
Aldosteron → 5α-dihydroaldosteron → 3α,5α-Tetrahydroaldosteron
5α-Dihydrodeoxycorticosteron → 3α,5α-Tetrahydrodeoxycorticosteron
Glukokortikoider
11-Deoxycortisol → Cortisol → 5α-Dihydrocortisol → 3α,5α-Tetrahydrocortisol
Cortison → 5α-dihydrocortison → 3α,5α-Tetrahydrocortison
5α-Dihydrodeoxycortisol → 3α,5α-Tetrahydrodeoxycortisol
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Fascillosteroider
(C-19: Androstanes ) |
11a-hydroxy
17α-OH: 11α-Hydroxyepiandrostanediol → 11α-Hydroxyepiandrostanediol → 5α-dihydro-11α-hydroxyepistosteron → 11α-hydroxyepiandrostanediol
17-O: 11α-hydroxydehydroepiandrosteron → 11α-hydroxyandrostenedion → 11α-hydroxyandrostenedion → 11α-hydroxyandrostenedion
17β-OH: 11α-hydroxyandrostenediol → 11α-hydroxytestosteron → 5α-dihydro-11α-hydroxytestosteron → 11α-hydroxyandrostenediol
11-keto
17α-OH: 11-ketoepiandrostanediol → 11-ketoepistosteron → 5α-dihydro-11-ketoepitestosteron → 11-ketoepiandrostanediol
17-O: 11-ketodehydroepiandrosteron → 11-ketoandrostenedion → 11-ketoandrostenedion → 11-ketoandrostenedion
17β-OH: 11-ketoandrostenediol → 11-ketotestosteron → 5α-dihydro-11-ketotestosteron → 11-ketoandrostenediol
11β-hydroxy
17α-OH: 11β-hydroxyepiandrostanediol → 11β-hydroxyepitaestosteron → 5α-dihydro-11β-hydroxyepitaestosteron → 11β-hydroxyepiandrostanediol
17-O: 11β-hydroxydehydroepiandrosteron → 11β-hydroxyandrostenedion → 11β-hydroxyandrostenedion → 11β-hydroxyandrostenedion
17β-OH: 11β-hydroxyandrostendiol → 11β-hydroxytestosteron → 5α-dihydro-11β-hydroxytestosteron → 11β-hydroxyandrostenediol
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Retikulosteroider
(C-18: Estranes ) |
Katekol-østrogener
17α-OH: 2-Hydroxyepiestradiol og 4-Hydroxyepiestradiol
17-O: 2-Hydroxyestron og 4-Hydroxyestron
17β-OH: 2-hydroxyestradiol og 4-hydroxyestradiol
Quinon-østrogener
17α-OH: 2,3-quinonepiestradiol og 4,3-quinonepiestradiol
17-O: 2,3-quinonestron og 4,3-quinonestron
17β-OH: 2,3-quinonestradiol og 4,3-quinonestradiol
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| Medullosteroider |
2,3-OH
DOPA → Dopamin → Noradrenalin → Adrenalin
3-OH
Tryptophan → 5-hydroxytryptophan → Serotonin → N-acetyl-5-hydroxytryptamin → Melatonin
3,4-OH
DOPA → Dopamin → Noradrenalin → Adrenalin
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